SERVIER STABLON COAXIL TIANEPTINE TATINOL TiANEURAX (NOOTROPIC MEDICATION MOOD BOOSTER AND ANTI DEPRESSENT)
MOOD LIFTER AND ENERGY BOOSTER (CLASSIFIED IN USA AS SUPPLEMENT FOR WELLBEING)
BEFORE MAKING ORDERS KINDLY ENSURE YOU CHECK WITH YOUR LOCAL PHYSICIANS AND ALSO LOCAL LAWS TO ENSURE COMPLIANCE WITH ALL LAWS IN ALL JURISDICTION.
Interest in Tianeptine has grown substantially in recent years.
In this guide we’ll weigh the benefits of Tianeptine against the risks, discuss the best practices for using Tianeptine, Tianeptine vendors, and finally compare Tianpetine sodium to Tianeptine
Is the Hype About Tianeptine Justified?
Well, it depends. If you’re a perfectly healthy, well-adjusted 18-30 year old with no family history of mental illness, probably not. But if you’ve ever had a mood disorder or struggled with anxiety, Tianeptine is absolutely all it’s cracked up to be.
This reflects a general trend with nootropics: they can iron out wrinkles in your cognitive landscape, but if you’re Richard Feynman, they probably won’t do much for you. In this vein, Adderall and modafinil may enhance cognition in a subset of healthy adults, but do nothing or even impair extremely high-functioning individuals. This stands to reason from an evolutionary standpoint. High-functioning individuals have hit a neurobiological ceiling. There’s just no room for improvement because everything is already optimized, by sequential improvements in fitness with each generation.
What is Tianeptine, Anyway?
Tianeptine is a prescription antidepressant in Europe. It’s a member of the old-school tricyclic class of antidepressants. Despite its chemical similarity, it shares very little with the tricyclics. It virtually lacks the anticholinergic, serotonergic, and noradrenergic effects of tricyclics.
Tianeptine can be purchased online with no legal repercussions (because it’s marketed as a dietary supplement in the US). No prescription required. It couldn’t be prescribed anyway, since it has never been evaluated, let alone approved, by the FDA. This does not reflect Tianeptine’s effectiveness as an antidepressant. It has to do with the insurmountable cost and financial risks of the FDA approval process.
What Does Tianeptine Do?
It does a lot of stuff, neurotransmitter-wise. It binds and activates mu-opioid receptors (the same receptors affected by painkillers). It was thought to clear serotonin from the synapse (“selective-serotonin re-uptake enhancement”). This view has mostly been rescinded. If Tianeptine does promote serotonin clearance at all, this effect is weak and doesn’t contribute to Tianeptine’s efficacy as an antidepressant.
Tianeptine also alters glutamate receptors in the brain. (Specifically, it modifies the phosphorylation state of these receptors, affecting signal transduction). Tianeptine possibly promotes mesolimbic dopamine release and potentiates dopamine receptors.
There’s sparse evidence to support this, but my view is that Tianeptine reproduces the beneficial effects of exercise on cognition. To oversimplify, the “runner’s high” is probably caused by the release of natural opioids, like endorphins (affectionately described as “endogenous morphine”). Since Tianeptine is a full agonist at the mu-opioid receptor, Tianeptine kind of behaves like an endorphin.
There are some other similarities between exercise and Tianeptine. Both “reverse stress-induced synaptic remodeling and impaired neuroplasticity.” There’s some truth there that’s co-mingled with bullshit. Neuroplasticity has become a dirty word:
The latest refrain in popular science is that ‘your brain is plastic’, that experience has the potential to ‘rewire’ your brain, and that many previous mysteries in cognitive science can be explained by ‘neuroplasticity’. What they don’t tell you is that these phrases are virtually meaningless.
Neuroplasticity sounds very technical, but there is no accepted scientific definition for the term and, in its broad sense, it means nothing more than ‘something in the brain has changed’. As your brain is always changing the term is empty on its own.
If endorphins are opiates and exercise-induced endorphin release alleviates depression, then…